C2 minidriver smart cards can be used with many Windows compatible Card/Certificate Management Systems, including Windows Forefront Identity Manager, 2FA ONE and Versatile Security's CMS series.
Other Certificate Authorities can also be used. Specifically, the Card Management System and Certificate Authority must support the Windows Smart Card subsystem, and the Windows Smart Card Base CSP.
Note that a Centralized Management System is not required. The smart cards can be managed with a Smart Card utility such as the Versatile Security CMS.